Nautient-II  

Native Undenatured Tertiary Intact Collagen Type II 
Application:  Joint health 
Dose:  40 mg/day 

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Nautient-II is the newest undenatured collagen for joint health promotion. Your trusted source of scientifically sound native undenatured tertiary intact collagen type II, extracted from European salmon nasal cartilage. Produced from high quality, sustainable and fresh Atlantic salmon off-cuts, through a proprietary, low-impact manufacturing process the product provides a superior nutritional profile and health promotional properties. HVEs production technology preserves the functional and nutritional value and allows the production of the highest quality undenatured and tertiary intact collagen type II in a fully sustainable fashion. 

Type II collagen and its function for joint health 

Type II collagen is the major protein in cartilage tissue, providing tensile strength and toughness to the tissue. Many joint disorders proceed through inflammatory pathways leading to cartilage degradation. This is majorly caused due to an immune response against endogenous type II collagen which is causing an inflammatory response. Type II collagen in its tertiary intact, undenatured form, at low dosing regime, acts as a modulator of the inflammatory immune response. 

Immune modulation mechanism of action  

Nautient-II works at very low dose (40 mg/day) through a mechanism called oral tolerance which provides a diminished immune response due to the build-up of receptor tolerance caused by low dose antigen recognition. Oral tolerance is effectuated by the following actions in the body: 

  1. Interaction of the orally ingested type II collagen with Peyer’s patches in the gut, potentiates detection by the immune system. 
  2. Low dose interaction initiates a continuous immune response against endogenous type II collagen thereby lowering the immunological action. 
  3. Providing immunological tolerance, the type II collagen leads to the reduction of collagen degradation in the joints, supporting overall joint health and anti-inflammation. 

Collagen peptides  

Salmon collagen peptides are the innovative salmon peptides comprising of majorly type I collagen providing excellent water solubility, easy digestion, high vitamin B12 content and a superior nutritional profile. Collagen peptides support the natural production of collagen in the body showcasing anti-aging benefits and providing a source of high quality building blocks for the regeneration of collagen in the body. 

Nautient-II 

  • New generation undenatured type II collagen and collagen peptides. 
  • Low dosing allowing the build-up of oral tolerance and reduction of inflammatory pathways.  
  • Science backed by demonstration in a plethora of scientific studies1-18: Effect on joint structure, improving knee discomfort and function, reducing inflammation. 
  • 100% European product, manufactured in The Netherlands.  

References 

  • 1. Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016 Jan 29;15:14. doi: 10.1186/s12937-016-0130-8. 
  • 2. Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013 Oct 24;10(1):48. doi: 10.1186/1550-2783-10-48. 
  • 3. Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21. doi: 10.7150/ijms.6.312.  
  • 4. Shiojima Y, Takahashi M, Takahashi R, Maruyama K, Moriyama H, Bagchi D, Bagchi M, Akanuma M. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study, Journal of the American Nutrition Association, 42:3, 224-241, doi: 10.1080/07315724.2021.2024466 
  • 5. Yoshinari O, Moriyama H, Shiojima Y, Miyawak H. Evaluation of Efficacy and Safety of NEXT-II®, a Novel Water-Soluble, Undenatured Type II Collagen in Subjects with Potential Risks in the Knee Joint Health from Healthy Population. Functional Foods in Health and Disease2015; 5(7):251-264. doi: 10.31989/ffhd.v5i7.187 
  • 6. Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016 Jun;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030. 
  • 7. Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10. PMID: 12837047. 
  • 8. Mehra A, Anand P, Borate M, Paul P, Kamble S, Mehta KD. A non-interventional, prospective, multicentricreal life Indian study to assess safety and effectiveness of un-denatured type 2 collagen in management of osteoarthritis. Int J Res Orthop2019;5:315-20. 
  • 9. Costa A, Cunha Teixeira V, Pereira M, Mota Ferreira P, Kuplich P, Dohnert M, da Silva Guths J, Boff Daitx R, Associated Strengthening Exercises to Undenatured Oral Type II Collagen (UC-II). A Randomized Study in Patients Affected by Knee Osteoarthritis. Muscles, Ligaments and Tendons Journal 2020;10 (3):481-492 
  • 10. Sadigursky D, Magnavita VFS, Sá CKC, Monteiro HS, Braghiroli OFM, Matos MAA. UNDENATURED COLLAGEN TYPE II FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE. Acta Ortop Bras. 2022 Apr 15;30(2):e240572. doi: 10.1590/1413-785220223002240572. 
  • 11. Jain A, Jain K, Vijayaraghavan N. AflaB2®and osteoarthritis: a multicentric, observational, post-marketing surveillance study in Indian patients suffering from knee osteoarthritis. Int J Res Orthop. 2021 Jan;7(1):110-11 doi: 10.18203/issn.2455-4510.IntJResOrthop20205570 
  • 12. McAlindony T, Nuitey M, Krishnanz N, Ruthazerx R, .Pricex L, Bursteink D, Griffith J, Flechsenhar K. Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. Osteoarthritis and Cartilage 19 (2011) 399-405. doi:10.1016/j.joca.2011.01.001 
  • 13. Kumar S, Sugihar, F, Suzuki K, Inoue N, Venkateswarathirukumara S.A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. J. Sci. Food Agric., 95: 702-707. doi:10.1002/jsfa.6752 
  • 14. Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016 Jun;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030. 
  • 15. Tomonaga A, Takahashi T, Tanaka YT, Tsuboi M, Ito K, Nagaoka I. Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double-blind placebo-controlled clinical study. Exp Ther Med. 2017 Jul;14(1):115-126. doi: 10.3892/etm.2017.4454. 
  • 16. Le T, Vu H, Arunasiri I, et al. Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model. Natural Product Communications. 2020;15(12). doi:10.1177/1934578X20982110 
  • 17. Yuriyama K. et al. Effects of Salmon Nasal Cartilage Extract Powder Standardized Undenatured Type ⅡCollagen and Proteoglycan on Knee Pain in Healthy Volunteers―A Single Center Randomized, Double—blind, Placebo—controlled Study：Re—analysis Results Focused on the Knee with Stronger Pain. Basic Pharmacology and Therapy Volume 48, Issue 11, 2011 – 2019 (2020) 
  • 18. Kim D, Chung H, Choi J, Sakai Y, Lee B. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018 Jun 26;10(7):826. doi: 10.3390/nu10070826. 
  • 19. Any of these statements have not been evaluated by competent food authorities. The product is not intended to diagnose, treat, cure or prevent any disease. This information is only for b-to-b and not meant to be addressed to final customers. The product may contain traces of other species than salmon 

About HVE Production Technologies BV 

HVE is a nutraceutical company employing a proprietary low impact extraction technology with the goal to make an impact in the development and manufacturing of active biomolecules for the nutraceutical market. 

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